Patterns of failure and prognosis in nasopharyngeal carcinoma according to Epstein-Barr virus DNA status.

ABSTRACT:

Purpose

To investigate the patterns of failure and prognosis in recurrent or metastatic nasopharyngeal carcinoma (rmNPC) according to Epstein-Barr virus-DNA (EBV-DNA) status.

Methods

We included NPC patients who were diagnosed with locoregional recurrence (LRR) and/(or) distant metastasis (DM) between January 2017 and June 2024. Receiver operating characteristic analysis, Chi-square test, Wilcoxon rank sum test, Kaplan-Meier method, and Multivariate Cox regression analyses were used for statistical analysis.

Results

This study involved 108 patients, including 105 (97.2%) who had EBV-DNA detectable at the initial diagnosis of NPC. Regarding progression patterns, 34 patients (31.5%) experienced only LRR, while 60 patients (55.6%) had only DM. LRR followed by DM was obse

SUBMITTER: Guo LF 

PROVIDER: S-EPMC11796219 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature