Antimicrobial peptide AP2 ameliorates Salmonella Typhimurium infection by modulating gut microbiota.

ABSTRACT:

Background

Endogenous antimicrobial peptides and proteins are essential for shaping and maintaining a healthy gut microbiota, contributing to anti-inflammatory responses and resistance to pathogen colonization. Salmonella enterica subsp. enterica serovar Typhimurium (ST) infection is one of the most frequently reported bacterial diseases worldwide. Manipulation of the gut microbiota through exogenous antimicrobial peptides may protect against ST colonization and improve clinical outcomes.

Results

This study demonstrated that oral administration of the antimicrobial peptide AP2 (2 µg /mouse), an optimized version of native apidaecin IB (AP IB), provided protective effects against ST infection in mice. These effects were evidenced by reduced ST-induced body weight loss and low

SUBMITTER: Li L 

PROVIDER: S-EPMC11796240 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature