SORFdb - a database for sORFs, small proteins, and small protein families in bacteria.

ABSTRACT: Small proteins with fewer than 100, particularly fewer than 50, amino acids are still largely unexplored. Nonetheless, they represent an essential part of bacteria's often neglected genetic repertoire. In recent years, the development of ribosome profiling protocols has led to the detection of an increasing number of previously unknown small proteins. Despite this, they are overlooked in many cases by automated genome annotation pipelines, and often, no functional descriptions can be assigned due to a lack of known homologs. To understand and overcome these limitations, the current abundance of small proteins in existing databases was evaluated, and a new dedicated database for small proteins and their potential functions, called 'sORFdb', was created. To this end, small proteins were extr

SUBMITTER: Hahnfeld JM 

PROVIDER: S-EPMC11796252 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature