A comprehensive transcriptional reference for severity and progression in spinal cord injury reveals novel translational biomarker genes.

ABSTRACT: Spinal cord injury (SCI) is a devastating condition that leads to motor, sensory, and autonomic dysfunction. Current therapeutic options remain limited, emphasizing the need for a comprehensive understanding of the underlying SCI-associated molecular mechanisms. This study characterized distinct SCI phases and severities at the gene and functional levels, focusing on biomarker gene identification. Our approach involved a systematic review, individual transcriptomic analysis, gene meta-analysis, and functional characterization. We compiled a total of fourteen studies with 273 samples, leading to the identification of severity- and phase-specific biomarker genes that allow the precise classification of transcriptomic profiles. We investigated the potential transferability of severity-specifi

SUBMITTER: Grillo-Risco R 

PROVIDER: S-EPMC11796280 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature