SignatureFinder enables sequence mining to identify cobalamin-dependent photoreceptor proteins.

ABSTRACT: Photoreceptors control cellular processes in response to light. Most photoreceptors sense blue or red light, but the recent discovery of the cobalamin-dependent photoreceptor, CarH, has expanded the wavelength range of photoreception to other regions of the electromagnetic spectrum to include the green light region. Further identification of cobalamin-dependent green light-sensitive photoreceptors has been hampered owing to poor annotation of the light responsiveness of cobalamin-binding domains (CBDs) in public databases. Here we report a computational workflow, SignatureFinder, that uses a combination of sequence and structural analyses to identify new light-responsive CBD-containing proteins. The light response of exemplar proteins containing the proposed signature were confirmed experi

SUBMITTER: Yu Y 

PROVIDER: S-EPMC11796333 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature