Activation and inhibition of sirtuins: From bench to bedside.

ABSTRACT: The sirtuin family comprises seven NAD⁺-dependent enzymes which catalyze protein lysine deacylation and mono ADP-ribosylation. Sirtuins act as central regulators of genomic stability and gene expression and control key processes, including energetic metabolism, cell cycle, differentiation, apoptosis, and aging. As a result, all sirtuins play critical roles in cellular homeostasis and organism wellness, and their dysregulation has been linked to metabolic, cardiovascular, and neurological diseases. Furthermore, sirtuins have shown dichotomous roles in cancer, acting as context-dependent tumor suppressors or promoters. Given their central role in different cellular processes, sirtuins have attracted increasing research interest aimed at developing both activators and inhibitors. I

SUBMITTER: Fiorentino F 

PROVIDER: S-EPMC11796339 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature