The palmitoyl-CoA ligase Fum16 is part of a <i>Fusarium verticillioides</i> fumonisin subcluster involved in self-protection.

ABSTRACT: Fusarium verticillioides produces the mycotoxin fumonisin B₁ (FB₁), which disrupts sphingolipid biosynthesis by inhibiting ceramide synthase and affects the health of plants, animals, and humans. The means by which F. verticillioides protects itself from its own mycotoxin are not completely understood. Some fumonisin (FUM) cluster genes do not contribute to the biosynthesis of the compound, but their function has remained enigmatic. Recently, we showed that FUM17, FUM18, and FUM19 encode two ceramide synthases and an ATP-binding cassette transporter, respectively, which play a role in antagonizing the toxicity mediated by FB₁. In the present work, we uncovered functions of two adjacent genes, FUM15 and FUM

SUBMITTER: Gherlone F 

PROVIDER: S-EPMC11796371 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature