<i>Acinetobacter baumannii</i> represses type VI secretion system through a manganese-dependent small RNA-mediated regulation.

ABSTRACT: Type VI secretion system (T6SS) is utilized by many Gram-negative bacteria to eliminate competing bacterial species and manipulate host cells. Acinetobacter baumannii ATCC 17978 utilizes T6SS at the expense of losing pAB3 plasmid to induce contact-dependent killing of competitor microbes, resulting in the loss of antibiotic resistance carried by pAB3. However, the regulatory network associated with T6SS in A. baumannii remains poorly understood. Here, we identified an Mn²⁺-dependent post-transcriptional regulation of T6SS mediated by a bonafide small RNA, AbsR28. A. baumannii utilizes MumT, an Mn²⁺-uptake inner membrane transporter, for the uptake of extracellular Mn²⁺ during oxidative stress. We demonstrate that the abundance of intrac

SUBMITTER: Bhowmik S 

PROVIDER: S-EPMC11796373 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature