Pseudovibriamides from <i>Pseudovibrio</i> marine sponge bacteria promote flagellar motility via transcriptional modulation.

ABSTRACT: Pseudovibrio α-Proteobacteria have been repeatedly isolated from marine sponges and proposed to be beneficial to the host. Bacterial motility is known to contribute to host colonization. We have previously identified pseudovibriamides A and B, produced in culture by Pseudovibrio brasiliensis Ab134, and shown that pseudovibriamide A promotes flagellar motility. Pseudovibriamides are encoded in a hybrid nonribosomal peptide synthetase-polyketide synthase gene cluster that also includes several accessory genes. Pseudovibriamide A is a linear heptapeptide and pseudovibriamide B is a nonadepsipeptide derived from pseudovibriamide A. Here, we define the borders of the pseudovibriamides gene cluster, assign function to biosynthetic genes using reverse genetics, and test the hypothes

SUBMITTER: Dai Y 

PROVIDER: S-EPMC11796379 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature