Transposon-sequencing across multiple <i>Mycobacterium abscessus</i> isolates reveals significant functional genomic diversity among strains.

ABSTRACT: Mycobacterium abscessus (Mab) is a clinically significant pathogen and a highly genetically diverse species due to its large accessory genome. The functional consequence of this diversity remains unknown mainly because, to date, functional genomic studies in Mab have been primarily performed on reference strains. Given the growing public health threat of Mab infections, understanding the functional genomic differences among Mab clinical isolates can provide more insight into how its genetic diversity influences gene essentiality, clinically relevant phenotypes, and importantly, potential drug targets. To determine the functional genomic diversity among Mab strains, we conducted transposon-sequencing (TnSeq) on 21 genetically diverse clinical isolates, inc

SUBMITTER: Akusobi C 

PROVIDER: S-EPMC11796383 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature