Delivery determinants of an <i>Acinetobacter baumannii</i> type VI secretion system bifunctional peptidoglycan hydrolase.

ABSTRACT: Acinetobacter baumannii is a Gram-negative opportunistic pathogen and is a common cause of nosocomial infections. The increasing development of antibiotic resistance in this organism is a global health concern. The A. baumannii clinical isolate AB307-0294 produces a type VI secretion system (T6SS) that delivers three antibacterial effector proteins that give this strain a competitive advantage against other bacteria in polymicrobial environments. Each effector, Tse15, Tde16, and Tae17, is delivered via a non-covalent interaction with a specific T6SS VgrG protein (VgrG15, VgrG16, and VgrG17, respectively). Here we define the regions of interaction between Tae17 and its cognate delivery protein VgrG17 and identify that amino acids G1069 and W1075 in VgrG17 are essential

SUBMITTER: Bezkorovayna V 

PROVIDER: S-EPMC11796386 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature