Short-term evolution and dispersal patterns of fluconazole-resistance in <i>Candida auris</i> clade III.

ABSTRACT: The rapid increase in infections caused by the emerging fungal pathogen Candida auris is of global concern, and understanding its expansion is a priority. The phylogenetic diversity of the yeast is clustered in five major clades, among which clade III is particularly relevant, as most of its strains exhibit resistance to fluconazole, reducing the therapeutic alternatives and provoking outbreaks that are difficult to control. In this study, we have investigated the phylogenetic structure of clade III by analyzing a global collection of 566 genomes. We have identified three subgroups within clade III, among which two are genetically most closely related. Moreover, we have estimated the evolutionary rate of clade III to be 2.25e-7 s/s/y (2.87 changes per year). We found that one of the

SUBMITTER: Cancino-Munoz I 

PROVIDER: S-EPMC11796387 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature