Sdd3 regulates the biofilm formation of <i>Candida albicans</i> via the Rho1-PKC-MAPK pathway.

ABSTRACT: Candida albicans, the most frequently isolated fungal pathogen in humans, forms biofilms that enhance resistance to antifungal drugs and host immunity, leading to frequent treatment failure. Understanding the molecular mechanisms governing biofilm formation is crucial for developing anti-biofilm therapies. In this study, we conducted a genetic screen to identify novel genes that regulate biofilm formation in C. albicans. One identified gene is ORF19.6693, a homolog of the Saccharomyces cerevisiae SDD3 gene. The sdd3∆/∆ mutant exhibited severe defects in biofilm formation and significantly reduced chitin content in the cell wall. Overexpression of the constitutively active version of the Rho1 GTPase Rho1^G18V, an upstream activator of the protein

SUBMITTER: Pang LM 

PROVIDER: S-EPMC11796410 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature