From structure prediction to function: defining the domain on the African swine fever virus CD2v protein required for binding to erythrocytes.

ABSTRACT: African swine fever virus (ASFV) is a high-consequence pathogen posing a substantial threat to global food security. This large DNA virus encodes more than 150 open reading frames, many of which are uncharacterized. The EP402R gene encodes CD2v, a glycoprotein expressed on the surface of infected cells and the only viral protein known to be present in the virus external envelope. This protein mediates binding of erythrocytes to both cells and virions. This interaction is known to prolong virus persistence in blood thus facilitating viral transmission. The sequence of the extracellular domain of CD2v shows similarity with that of mammalian CD2 proteins and is therefore likely to feature two immunoglobulin (Ig)-like domains. A combination of protein structure modeling and extensive mu

SUBMITTER: Reis AL 

PROVIDER: S-EPMC11796414 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature