Inhibition and evasion of neutrophil microbicidal responses by <i>Legionella longbeachae</i>.

ABSTRACT: Legionella species evade degradation and proliferate within alveolar macrophages as an essential step for the manifestation of disease. However, most intracellular bacterial pathogens are restricted in neutrophils, which are the first line of innate immune defense against invading pathogens. Bacterial degradation within neutrophils is mediated by the fusion of microbicidal granules to pathogen-containing phagosomes and the generation of reactive oxygen species (ROS) by the phagocyte NADPH oxidase complex. Here, we show that human neutrophils fail to trigger microbicidal processes and, consequently, fail to restrict L. longbeachae. In addition, neutrophils infected with L. longbeachae fail to undergo a robust pro-inflammatory response, such as degranulation and IL-8 pro

SUBMITTER: Hanford HE 

PROVIDER: S-EPMC11796426 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature