MalKinID: A classification model for identifying malaria parasite genealogical relationships using identity-by-descent.

ABSTRACT: Pathogen genomics is a powerful tool for tracking infectious disease transmission. In malaria, identity-by-descent is used to assess the genetic relatedness between parasites and has been used to study transmission and importation. In theory, identity-by-descent can be used to distinguish genealogical relationships to reconstruct transmission history or identify parasites for QTL experiments. MalKinID (Malaria Kinship Identifier) is a new classification model designed to identify genealogical relationships among malaria parasites based on genome-wide identity-by-descent proportions and identity-by-descent segment distributions. MalKinID was calibrated to the genomic data from 3 laboratory-based genetic crosses (yielding 440 parent-child and 9060 full-sibling comparisons). MalKinID identifi

SUBMITTER: Wong W 

PROVIDER: S-EPMC11796457 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature