Different complex regulatory phenotypes underlie hybrid male sterility in divergent rodent crosses.

ABSTRACT: Hybrid incompatibilities are a critical component of species barriers and may arise due to negative interactions between divergent regulatory elements in parental species. We used a comparative approach to identify common themes in the regulatory phenotypes associated with hybrid male sterility in two divergent rodent crosses, dwarf hamsters and house mice. We investigated three potential characteristic gene expression phenotypes in hybrids including the propensity of transgressive differentially expressed genes toward over or underexpression, the influence of developmental stage on patterns of misexpression, and the role of the sex chromosomes on misexpression phenotypes. In contrast to near pervasive overexpression in hybrid house mice, we found that misexpression in hybrid dwarf hamster

SUBMITTER: Hunnicutt KE 

PROVIDER: S-EPMC11796465 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature