In search of effective therapies: the current landscape of phase II trials in patients with advanced soft tissue sarcoma.

ABSTRACT:

Purpose

Soft tissue sarcomas (STS) are diagnosed in 4-6 cases per 100 000 people a year and are associated with an unfavorable prognosis. Around one-third of patients will develop metastatic disease that requires palliative systemic therapy. Current therapeutic options have limited activity, and new treatments are tested, mainly in phase II trials. There is high variability and no standardization of phase II designs. We aimed to analyze the current landscape of phase II studies in STS and evaluate how its statistical design can affect the results.

Methods

Full-text phase II studies published in STS patients between 2005 and 2020 were identified and analyzed.

Results

We have identified 102 trials, of which 77.4% were single-arm trials, 16.7% were randomized comparative

SUBMITTER: Sobczuk P 

PROVIDER: S-EPMC11796629 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature