Driver and targetable alterations in Chinese patients with small bowel carcinoma.

ABSTRACT:

Purpose

Small bowel carcinoma (SBA) is a rare gastrointestinal cancer with a poor prognosis. Recent genomic profiling studies revealed that the landscape of molecular alterations in SBA was distinct from colorectal cancer (CRC) and gastric cancer (GC). To explore driver and targetable alterations in SBA, we performed next-generation sequencing in 107 Chinese SBA patients.

Methods

DNA from paraffin-embedded SBA samples and the corresponding peripheral blood control samples were analyzed through a next-generation sequencing panel. Somatic alterations including point mutations, indels, copy number alterations, gene fusions as well as pathogenic germline variants were characterized.

Results

More than half of SBA cases carried KRAS mutations, including canonical (G12, G12,

SUBMITTER: Li J 

PROVIDER: S-EPMC11796673 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature