DNA methylation-related lncRNAs predict prognosis and immunotherapy response in gastric cancer.

ABSTRACT:

Background

LncRNAs and DNA methylation are both key regulators of tumorigenesis and immune regulation. However, the interaction between lncRNA and DNA methylation, their regulation and their clinical and immune relevance in gastric cancer (GC) remain unclear.

Methods

In this study, we identified DNA methylation regulator-related lncRNAs through Pearson correlation analysis in The Cancer Genome Atlas datasets. Univariate Cox regression was used to screen DNA methylationrelated prognostic lncRNAs. Further, through least absolute shrinkage and selection operator Cox regression, a prognostic model based on 13 lncRNAs was established. Survival analysis and receiver operating characteristic curve analysis verified the accuracy of the model in predicting the survival of GC patients

SUBMITTER: Guo X 

PROVIDER: S-EPMC11796752 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature