Controlling the frequency dynamics of homing gene drives for intermediate outcomes.

ABSTRACT: Gene drives have enormous potential for solving biological issues by forcing the spread of desired alleles through populations. However, to safeguard from the potentially irreversible consequences on natural populations, gene drives with intermediate outcomes that neither fixate nor get removed from the population are of outstanding interest. To elucidate the conditions leading to intermediate gene drive outcomes, a stochastic, individual allele-focused gene drive model was developed to simulate the diffusion of a homing gene drive in a population. The frequencies of multiple alleles at a locus targeted by a gene drive were tracked under various scenarios. These explored the effect of gene drive conversion efficiency, strength and frequency of resistance alleles, dominance and strength of

SUBMITTER: Camm BJ 

PROVIDER: S-EPMC11797013 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature