Sex-specific genetic architecture of blood pressure.

ABSTRACT: The genetic and genomic basis of sex differences in blood pressure (BP) traits remain unstudied at scale. Here, we conducted sex-stratified and combined-sex genome-wide association studies of BP traits using the UK Biobank resource, identifying 1,346 previously reported and 29 new BP trait-associated loci. Among associated loci, 412 were female-specific (P_female ≤ 5 × 10^-8; P_male > 5 × 10^-8) and 142 were male-specific (P_male ≤ 5 × 10^-8; P_female > 5 × 10^-8); these sex-specific loci were enriched for hormone-related transcription factors, in particular, estrogen receptor 1. Analyses of gene-by-sex interactions and sexually dimorphic effects identified four genomic regions, showing female-specific associat

SUBMITTER: Yang ML 

PROVIDER: S-EPMC11797078 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature