Metabolic pathway-based molecular subtyping of colon cancer reveals clinical immunotherapy potential and prognosis.

ABSTRACT:

Purpose

Colon cancer presents challenges to clinical diagnosis and management due to its high heterogeneity. For more efficient and convenient diagnosis and treatment of colon cancer, we are committed to characterizing the molecular features of colon cancer by pioneering a classification system based on metabolic pathways.

Methods

Based on the 113 metabolic pathways and genes collected in the previous stage, we scored and filtered the metabolic pathways of each sample in the training set by ssGSEA, and obtained 16 metabolic pathways related to colon cancer recurrence. In consistent clustering of training set samples with recurrence-related metabolic pathway scores, we identified two robust molecular subtypes of colon cancer (MC1 and MC2). Furthermore, we performed multi-angl

SUBMITTER: Dai Z 

PROVIDER: S-EPMC11797159 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature