Tumor-infiltrating CD226⁺CD8⁺ T cells are associated with postoperative prognosis and adjuvant chemotherapeutic benefits in gastric cancer patients.

ABSTRACT:

Purpose

Defining the phenotypic characteristics of CD8⁺ T cell subsets in gastric cancer (GC) can help remodel the immune microenvironment of the tumor, thereby improving patient prognosis. CD226 has recently been shown to regulate the activity of CD8⁺ T cell in several malignancies. However, the clinical relevance of CD226⁺CD8⁺ T cells in GC remains unclear.

Methods

Fudan University Shanghai Cancer Center (FUSCC) cohort (n = 316), The Cancer Genome Atlas (TCGA) cohort (n = 407), KUGH/KUCM cohort (n = 202), and Asian Cancer Research Group (ACRG) cohort (n = 300) were included in prognosis and response to adjuvant chemotherapy (ACT) analyses. Flow cytometry and multiplex immunostaining were used to characterize CD226⁺CD8<

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11797177 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature