A pairwise immune gene model for predicting overall survival and stratifying subtypes of colon adenocarcinoma.

ABSTRACT:

Objectives

There is increasing evidence for a close correlation between risk stratification, prognosis and the immune environment in colon adenocarcinoma (COAD). However, the efficacy of immunotherapy is different among different patients with COAD. Therefore, the current work tends to use immune-related gene to develop a gene-pair model to evaluate the COAD prognosis, and to develop a new method for risk stratification of COAD, which is conducive to better predict the immunotherapy effect of patients.

Methods

Specifically, from the TCGA and GEO (GSE14333 and GSE39582) databases, we first collected gene expression profiles, associated survival follow-up information of COAD patients. Through systematic bioinformatics analysis, we established a prognosis-related model of colon

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC11797178 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature