Diagnostic, prognostic, and immunological roles of CD177 in cervical cancer.

ABSTRACT:

Background

CD177, an indicator of prognosis in diverse cancers, is involved in the physiological processes of various tumor cells, and acts as an immune molecule with novel functions in cancer pathogenesis. However, the diagnostic, prognostic, and immunological role of CD177 in cervical cancer remains unclear.

Methods

Utilizing publicly available databases and integrating several bioinformatics analysis methods, we evaluated the expression level of CD177 in cervical cancer by GENT2, HPA, and GEO databases. And the experiments of western blot and immunohistochemical staining were used to test the hypothesis. The Kaplan-Meier Plotter database, Xena Shiny, and the constructed nomogram were clearly demonstrated its prognostic value for patients. Gene set enrichment analysis expl

SUBMITTER: Liao W 

PROVIDER: S-EPMC11797183 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature