Prognostic and immune correlation analysis of mitochondrial autophagy and aging-related genes in lung adenocarcinoma.

ABSTRACT:

Purpose

Mitophagy and aging (MiAg) are very important pathophysiological mechanisms contributing to tumorigenesis. MiAg-related genes have prognostic value in lung adenocarcinoma (LUAD). However, prognostic, and immune correlation studies of MiAg-related genes in LUAD are lacking.

Methods

MiAg differentially expressed genes (DEGs) in LUAD were obtained from public sequencing datasets. A prognostic model including MiAg DEGs was constructed according to patients divided into low- and high-risk groups. Gene Ontology, gene set enrichment analysis, gene set variation analysis, CIBERSORT immune infiltration analysis, and clinical characteristic correlation analyses were performed for functional annotation and correlation of MiAgs with prognosis in patients with LUAD.

Results

SUBMITTER: Meng X 

PROVIDER: S-EPMC11797264 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature