RNA polymerase II coordinates histone deacetylation at active promoters.

ABSTRACT: Nucleosomes at promoters of active genes are marked by specific histone post-translational modifications and histone variants. These features are thought to promote the formation and maintenance of an "open" chromatin environment that is suitable for transcription. However, recent reports have drawn conflicting conclusions about whether these histone modifications depend on active transcription. To further interrogate this relationship, we inhibited transcription initiation using triptolide, which triggered degradation of RNA polymerase II, and examined the impact on histone modifications. Transcription initiation was not required for either hormone-induced or steady-state active histone modifications at transcription start sites (TSSs) and enhancers. Rather, blocking transcription initiat

SUBMITTER: Hoffman JA 

PROVIDER: S-EPMC11797538 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature