Role of von Willebrand factor (VWF), platelets, and aberrant flow in the initiation of venous thrombosis.

ABSTRACT: Deep vein thrombosis is a major cause of morbidity and mortality worldwide. However, because of the absence of overt blood vessel damage, how venous thrombosis is actually initiated remains unclear. Using endothelialized fluidic devices, we show that aberrant flow patterns that may occur in venous valve pockets of individuals with common stasis-related risk factors can cause the formation of von Willebrand factor-platelet tangles that are resistant to ADAMTS13 removal. These von Willebrand factor-bound platelets specifically recruit neutrophils in a manner that is dependent on platelet-activated α_IIbβ₃, neutrophil SLC44A2, and endothelial P-selectin. The interaction of SLC44A2 with activated α_IIbβ₃ promotes formation of prothrombotic neutrophil e

SUBMITTER: Mereweather LJ 

PROVIDER: S-EPMC11797557 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature