Construction of cuproptosis signature based on bioinformatics and experimental validation in clear cell renal cell carcinoma.

ABSTRACT:

Background

Cuproptosis was defined as a novel nonapoptotic cell death pathway and its potential function in clear cell renal cell carcinoma (ccRCC) remains unclear.

Methods

We obtained gene expression profiles, somatic mutation and corresponding clinical information of 881 ccRCC samples from 3 cohorts including the cancer genome atlas cohort, GSE29609 cohort and CheckMate 025 cohort. As described in the latest published article, we enrolled 16 genes as cuproptosis-related genes (CRGs). We explored the expression level, variants and copy number variation of the CRGs. Univariate and multi-variate regression were utilized to assess the prognostic significance of the CRGs. Non-negative matrix factorization was used to identify potential subgroup and gene set variation analysis w

SUBMITTER: Tian X 

PROVIDER: S-EPMC11797599 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature