Blood-based T cell receptor anti-viral CDR3s are associated with worse overall survival for neuroblastoma.

ABSTRACT: With the advent of large collections of adaptive immune receptor recombination reads representing cancer, there is the opportunity to further investigate the adaptive immune response to viruses in the cancer setting. This is a particularly important goal due to longstanding but still not well-resolved questions about viral etiologies in cancer and viral infections as comorbidities. In this report, we assessed the T cell receptor complementarity determining region-3 (CDR3) amino acid (AA) sequences, for blood-sourced TCRs from neuroblastoma (NBL) cases, for exact AA sequence matches to previously identified anti-viral TCR CDR3 AA sequences. Results indicated the presence of anti-viral TCR CDR3 AA sequences in the NBL blood samples highly significantly correlated with worse overall survival.

SUBMITTER: Kacsoh DB 

PROVIDER: S-EPMC11797736 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature