Serum MMP-8 and TIMP-1 concentrations in a population-based cohort: effects of age, gender, and health status.

ABSTRACT:

Background

Matrix-degrading proteinases and their regulators, such as matrix metalloproteinase 8 (MMP-8) and tissue inhibitor of matrix metalloproteinase 1 (TIMP-1), may contribute to various pathological events. Elevated MMP-8 concentrations have been associated with e.g., cardiovascular diseases and periodontitis. However, there is little knowledge on the physiological concentrations of these molecules in serum, or the effect of demographic or lifestyle factors on their levels.

Design and methods

We investigated the effect of various demographic characteristics and behavioral habits, such as aging, sex, smoking, and BMI, on serum concentrations of MMP-8 and TIMP-1. We used the FINRISK97 cohort (n = 8,446), which has comprehensive information on demographic and lifes

SUBMITTER: Ranta J 

PROVIDER: S-EPMC11797797 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature