Genetic analysis of potential markers and therapeutic targets for immunity in periodontitis.

ABSTRACT:

Objective

Periodontitis is a chronic inflammatory periodontal disease resulting in destroyed periodontal tissue. Many studies have found that the host's inflammatory immune responses are involved in the risk of periodontal tissue damage. In this study, we aim to identify potential biomarkers and therapeutic targets related to immunity in periodontitis.

Methods

GSE16134 and GSE10334 were downloaded from the Gene Expression Omnibus (GEO) database, and the immune-related genes were obtained from the Immunology Database and Analysis Portal (ImmPort). After the differentially expressed immune-related genes (DE-IRGs) were identified, enrichment analysis was performed. Two machine learning methods, the least absolute shrinkage and selector operation (LASSO) logistic regression and

SUBMITTER: Li H 

PROVIDER: S-EPMC11797874 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature