Characterising the Time Course of the Dilatory Response of Healthy Retinal Arteries during Flicker-Light Provocation.

ABSTRACT:

Introduction

The dilatory response of healthy retinal arterioles to flicker-light (FL) provocation appears to be biphasic. The vessel diameter rapidly increases (acute phase) over 5-10 s, then barely increases thereafter (maintenance phase) until FL cessation. This reaction is usually characterised at a single point by two parameters: maximum dilation (MD) relative to baseline diameter (MD, %) and time to MD (RT, s). This paper describes the biphasic reaction of retinal arteries during FL provocation using a bi-linear function.

Methods

Retinal arterioles from 45 adults were examined during flicker provocation. Each individual time course of arterial diameter change during FL provocation was characterised by a bi-linear equation and compared with MD and RT.

Results

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SUBMITTER: Summers RJ 

PROVIDER: S-EPMC11797924 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature