MicroRNA-21-5p profile in the alveolar bone following tooth extraction in medication-related osteonecrosis of the jaw rat model.

ABSTRACT:

Objective

This study aimed to compare microRNA-21-5p expressions at the extraction wound in the maxillary bones of rats with medication-related osteonecrosis of the jaw (MRONJ) and normal rats at different time points.

Materials and methods

In total, 18 female, 8-week-old Sprague-Dawley rats were randomly assigned to the experimental group (n = 9) and the control group (n = 9). To establish MRONJ in the right maxillary first molar area in the experimental group, zoledronate (66 µg/kg) and dexamethasone (5 mg/kg) were administered intraperitoneally every other day for 2 weeks before tooth extraction. Normal saline was administered in the control group. After tooth extraction, the drugs were continuously administered until the experimental endpoints, namely 1, 14

SUBMITTER: Morakotsriwan M 

PROVIDER: S-EPMC11797932 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature