Prognostic and Clinical Significance of the Proliferation Marker MCM7 in Breast Cancer.

ABSTRACT:

Introduction

Minichromosome maintenance complex component 7 (MCM7) plays an essential role in proliferation and DNA replication of cancer cells. However, the expression and prognostic significance of MCM7 in breast cancer (BC) remain to be defined. In this study, we aimed to evaluate the role of MCM7 in BC.

Methods

We conducted immunohistochemistry staining of MCM7 in 1,156 operable early-stage BC samples and assessed MCM7 at the transcriptomic levels using publicly available cohorts (n = 13,430). MCM7 expression was evaluated and correlated with clinicopathological parameters including Ki67 labelling index and patient outcome.

Results

At the transcriptomic level, there was a significant association between high MCM7 mRNA levels and shorter patient survival in the who

SUBMITTER: Lashen AG 

PROVIDER: S-EPMC11797933 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature