A promising anoikis-related prognostic signature predicts prognosis of skin cutaneous melanoma.

ABSTRACT:

Background

Skin cutaneous melanoma (SKCM) is a highly aggressive disease with a poor prognosis for advanced tumors. Anoikis is a caspase-dependent cell death process triggered by extracellular matrix (ECM) detachment, rectifies detachment-induced metabolic defects that compromise cell survival, recent study revealed the crucial role of anoikis for cancer cells to survive during metastasis. However, limited research focused on the role of anoikis in SKCM.

Methods

Our study utilized the 27 anoikis-related genes (ARGs) to divide SKCM patients into two clusters, and obtain differentially expressed genes (DEGs) for each cluster. These DEGs were used in stepwise Cox regression analysis to develop a prediction model for SKCM patients consisting of nine ARGs, called the anoikis-rela

SUBMITTER: Yue Z 

PROVIDER: S-EPMC11797965 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature