Decreased erythrocyte aggregation in Glenn and Fontan: univentricular circulation as a rheologic disease model.

ABSTRACT:

Background

In the Fontan palliation for single ventricle heart disease (SVHD), pulmonary blood flow is non-pulsatile/passive, low velocity, and low shear, making viscous power loss a critical determinant of cardiac output. The rheologic properties of blood in SVHD patients are essential for understanding and modulating their limited cardiac output and they have not been systematically studied. We hypothesize that viscosity is decreased in single ventricle circulation.

Methods

We evaluated whole blood viscosity, red blood cell (RBC) aggregation, and RBC deformability to evaluate changes in healthy children and SVHD patients. We altered suspending media to understand cellular and plasma differences contributing to rheologic differences.

Results

Whole blood viscosity was

SUBMITTER: Suriany S 

PROVIDER: S-EPMC11798010 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature