Canine immune cells express high levels of CB₁ and CB₂ cannabinoid receptors and cannabinoid-mediated alteration of canine cytokine production is vehicle-dependent.

ABSTRACT: With the increased popularity and societal acceptance of marijuana and cannabidiol (CBD) use in humans, there is an interest in using cannabinoids in veterinary medicine. There have been a few placebo-controlled clinical trials in dogs suggesting that cannabis-containing extracts are beneficial for dogs with inflammatory diseases such as osteoarthritis, and there is growing interest in their immunosuppressive potential for the treatment of immune-mediated diseases. Since cannabinoids exhibit anti-inflammatory and immunosuppressive effects in many species, the purpose of these studies was to examine whether the plant-derived cannabinoids, CBD and Δ⁹-tetrahydrocannabinol (THC), would also suppress immune function in canine peripheral blood mononuclear cells (PBMCs). Another goal w

SUBMITTER: Brown C 

PROVIDER: S-EPMC11798033 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature