Causal relationship between lung diseases and risk of esophageal cancer: insights from Mendelian randomization.

ABSTRACT:

Background

An increasing number of cohort studies have indicated a correlation between lung diseases and esophageal cancer, but the exact causal relationship has not been definitively established. Therefore, the objective of this study is to assess the causal relationship between lung diseases and esophageal cancer.

Methods

Single-nucleotide polymorphisms (SNPs) related to lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), lung cancer, and idiopathic pulmonary fibrosis (IPF), along with outcomes data on esophageal cancer, were extracted from public genome-wide association studies (GWAS). A two-sample Mendelian randomization (MR) analysis was then performed using publicly available GWAS data to investigate the potential causal relationship. The effect

SUBMITTER: Zhou J 

PROVIDER: S-EPMC11798119 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature