Mechanistic insights into super-enhancer-driven genes as prognostic signatures in patients with glioblastoma.

ABSTRACT:

Background

Glioblastoma (GBM) is one of the most common malignant brain tumors in adults and is characterized by high aggressiveness and rapid progression, poor treatment, high recurrence rate, and poor prognosis. Although super-enhancer (SE)-driven genes haven been recognized as prognostic markers for several cancers, whether it can be served as effective prognostic markers for patients with GBM has not been evaluated.

Methods

We first combined histone modification data with transcriptome data to identify SE-driven genes associated with prognosis in patients with GBM. Second, we developed a SE-driven differentially expressed genes (SEDEGs) risk score prognostic model by univariate Cox analysis, KM survival analysis, multivariate Cox analysis and least absolute shrinkage and

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11798175 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature