Multi-omics analysis of expression profile and prognostic values of connexin family in LUAD.

ABSTRACT:

Purpose

Our study first explored the expression differences and prognostic significance of Cx genes in pan-cancer and then focused on LUAD. Our objectives were to conducted a comprehensive analysis of the expression profile, prognostic significance, genetic alterations, potential biological functions and drug sensitivity of the Connexin gene family in LUAD.

Methods

We developed a comprehensive prognostic model for LUAD by combining risk scores with clinical features and created a nomogram to predict 1-, 3-, and 5-year overall survival. Using single-cell sequencing, we examined the expression and biological functions of the identified prognostic markers.

Results

Our risk model revealed that GJB2-5 play a critical role in the prognosis of LUAD patients, associated with

SUBMITTER: Jiang P 

PROVIDER: S-EPMC11798253 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature