Characterization of stem cell subtypes and prognostic signature in hepatocellular carcinoma.

ABSTRACT:

Background

Cancer stem cells (CSCs) were linked to cancer aggressiveness and poor prognosis in patients with hepatocellular carcinoma (HCC).

Methods

We integrated two external HCC cohorts to develop the stem cell subtypes according to unsupervised clustering with 26 stem cell gene sets. Between the subtypes, differences in prognosis, clinical characteristics, recognized HCC subtypes, metabolic profile, immune-related features, somatic mutation, and drug sensitivity were examined. The prognostic signature was created, and validated by numerous cohorts, and used to assess the efficacy of immunotherapy and transcatheter arterial chemoembolization (TACE) treatment. The nomogram was developed based on the signature and clinical features. We further examined the function of KIF20A

SUBMITTER: Qiu C 

PROVIDER: S-EPMC11798313 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature