Gli1⁺ Periodontal Mesenchymal Stem Cells in Periodontitis.

ABSTRACT: Periodontal mesenchymal stem cells (MSCs) play a crucial role in maintaining periodontium homeostasis and in tissue repair. However, little is known about how periodontal MSCs in vivo respond under periodontal disease conditions, posing a challenge for periodontium tissue regeneration. In this study, Gli1 was used as a periodontal MSC marker and combined with a Gli1-cre ERT2 mouse model for lineage tracing to investigate periodontal MSC fate in an induced periodontitis model. Our findings show significant changes in the number and contribution of Gli1⁺ MSCs within the inflamed periodontium. The number of Gli1⁺ MSCs that contributed to periodontal ligament homeostasis decreased in the periodontitis-induced teeth. While the proliferation of Gli1⁺ MSCs had no

SUBMITTER: Deng Y 

PROVIDER: S-EPMC11798346 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature