The use of tier three therapies in acute brain injured patients: Insight from the Extubation strategies in Neuro-Intensive care unit patients and associations with Outcomes observational study.

ABSTRACT:

Background

In patients with acute brain injury (ABI) and refractory intracranial hypertension, the so-called 'tier three therapies' (TTT) (hypothermia, metabolic suppression with barbiturates, and decompressive craniectomy) may be used.

Objective

We aimed to describe the incidence of use of TTT, and to assess their effect on outcome.

Design

A secondary analysis of the ENIO observational study.

Setting

Seventy-three intensive care units (ICUs) in 18 countries worldwide between June 2018 and November 2020.

Patients

One thousand five hundred and twelve adult patients admitted to an intensive care unit (ICU) with ABI were included and categorised according to use or not of one or more TTT.

Results

Three hundred and ninety-six patients (26.2%) received

SUBMITTER: Iaquaniello C 

PROVIDER: S-EPMC11798370 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature