Allele-specific methylation of SSTR4 associated with aging and cognitive functions in patients with schizophrenia.

ABSTRACT: The co-occurrence of alcohol use disorder (AUD) and schizophrenia is prevalent, with a rate of 33.7%. Previous research has suggested a genetic and epigenetic overlap between these two disorders. SSTR4, a member of the somatostatin receptor family, is implicated in various neurological and psychiatric conditions, including cognitive function, AUD, and schizophrenia. However, the role of genetic-epigenetic interactions involving SSTR4 in patients with schizophrenia remains unexplored. In this study, we conducted an integration of publicly available datasets and identified allele-specific methylation patterns in SSTR4. Additionally, we pinpointed several genetic variants (rs17691954, rs11464356, rs3109190, and rs145879288) that influence the pace of aging and cognitive functions (rs705935) t

SUBMITTER: Zhao R 

PROVIDER: S-EPMC11798447 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature