HCNetlas: A reference database of human cell type-specific gene networks to aid disease genetic analyses.

ABSTRACT: Cell type-specific actions of disease genes add a significant layer of complexity to the genetic architecture underlying diseases, obscuring our understanding of disease mechanisms. Single-cell omics have revealed the functional roles of genes at the cellular level, identifying cell types critical for disease progression. Often, a gene impact on disease through its altered network within specific cell types, rather than mere changes in expression levels. To explore the cell type-specific roles of disease genes, we developed HCNetlas (human cell network atlas), a resource cataloging cell type-specific gene networks (CGNs) for various healthy tissue cells. We also devised 3 network analysis methods to investigate cell type-specific functions of disease genes. These methods involve comparing

SUBMITTER: Yu J 

PROVIDER: S-EPMC11798474 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature