Parabrachial CGRP neurons modulate active defensive behavior under a naturalistic threat.

ABSTRACT: Recent studies suggest that calcitonin gene-related peptide (CGRP) neurons in the parabrachial nucleus (PBN) represent aversive information and signal a general alarm to the forebrain. If CGRP neurons serve as a true general alarm, their activation would modulate both passive nad active defensive behaviors depending on the magnitude and context of the threat. However, most prior research has focused on the role of CGRP neurons in passive freezing responses, with limited exploration of their involvement in active defensive behaviors. To address this, we examined the role of CGRP neurons in active defensive behavior using a predator-like robot programmed to chase mice. Our electrophysiological results revealed that CGRP neurons encode the intensity of aversive stimuli through variations in f

SUBMITTER: Pyeon GH 

PROVIDER: S-EPMC11798572 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature