Chronic cannabis use differentially modulates neural oscillations serving the manipulate versus maintain components of working memory processing.

ABSTRACT: The legalization of recreational cannabis use has expanded the availability of this psychoactive substance in the United States. Research has shown that chronic cannabis use is associated with altered working memory function, however, the brain areas and neural dynamics underlying these affects remain poorly understood. In this study, we leveraged magnetoencephalography (MEG) to investigate neurophysiological activity in 45 participants (22 heavy cannabis users) during a numerical WM task, whereby participants were asked to either maintain or manipulate (i.e., rearrange in ascending order) a group of visually presented numbers. Significant oscillatory responses were imaged using a beamformer and subjected to whole-brain ANOVAs. Notably, we found that cannabis users exhibited significantly

SUBMITTER: Huang PJ 

PROVIDER: S-EPMC11798582 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature