Multimodal neuroimaging biomarkers and subtle cognitive decline in a population-based cohort without dementia.

ABSTRACT:

Background

The relationship between subtle cognitive decline and Alzheimer's disease (AD) pathology as measured by biomarkers in settings outside of specialty memory clinics is not well characterized.

Objective

To investigate how subtle longitudinal cognitive decline relates to neuroimaging biomarkers in individuals drawn from a population-based study in an economically depressed, small-town area in southwestern Pennsylvania, USA.

Methods

A subset of participants without dementia (N = 115, age 76.53 years ± 6.25) from the Monongahela Youghiogheny Healthy Aging Team (MYHAT) study completed neuroimaging including magnetic resonance imaging (MRI) measures of AD-signature region cortical thickness and white matter hyperintensities (WMH), Pittsburgh compound B (PiB)-positr

SUBMITTER: Weinstein AM 

PROVIDER: S-EPMC11798718 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature